The win saw the Rockets improve to 11-3 at the top of the Western Conference, neck-and-neck with the pace-setting Los Angeles Lakers (11-2).
Buddy Hield scored a season-high 35 points for Kings
George scored 33 points in his season debut Thursday in a loss to the New Orleans Pelicans.
Russell suffered the setback Friday in the Warriors' 105-100 home loss to Boston and an MRI exam confirmed the extent of the injury.
LeBron James, Anthony Davis star as Los Angeles Lakers beat Sacramento Kings.
Miami Heat held on for a 108-97 victory over the Cleveland Cavaliers.
Harden led the scoring with 47 points, including seven three-pointers, while the former NBA MVP also added six rebounds and seven assists.
A LeBron James three-pointer put the Lakers 114-113 ahead before Kuzma weighed in to stretch the lead to 120-113.
The 31-year-old veteran 3-point sharpshooter, in his 11th NBA season, is set to miss the most games of any campaign in his career with his worst injury setback.
Leonard had 12 points, 11 rebounds and nine assists but shot only 2-of-11 from the floor and 0-of-4 from three-point range.
Siakam is helping Raptor fans forget about the loss of NBA finals MVP Kawhi Leonard to the Los Angeles Clippers.
Davis finished with a team-leading 26 points and eight rebounds and James scored 12 of his 25 points in the fourth quarter for the Lakers who are also 4-0 at home.
Spurs defeated the Oklahoma City Thunder 121-112 as LaMarcus Aldridge scored 39 points.
Donovan Mitchell scored 24 points for Jazz while Bojan Bogdanovic finished with 20 points and six rebounds.
James scored 30 points, grabbed 10 rebounds and passed off 11 assists.