The 34-year-old is just four stage wins shy of equalling Belgian legend Eddie Mercx's record of 34 stage victories in the Tour de France.
Avermaet, 35, was joined by 12 other cyclists in racing the final 32km of 'De Ronde'.
The 13-man field in the online race broadcast on TV, led by defending champion Alberto Bettiol, will race 32km on rollers from the confinement of their own homes.
The tour, scheduled for June 7-14, had been the earliest top-level race still standing on the cycling calendar.
The COVID-19 death toll in Spain topped 10,000 on Thursday, making it the second worst-hit nation behind Italy.
However, the Tour de France, due to start in Nice on June 27, remains on schedule.
A series of challenges and races will be run on the Zwift virtual cycling platform.
The highlight of the French sporting calendar is due to embark from Nice on June 27 and end on the Champs-Elysees in Paris on July 19.
The 25-year-old of Team UAE Emirates contracted the disease during last month's Emirates Tour that was canceled on February 27 after several riders caught the virus.
The race was one of the rare sporting events to escape postponement due to the coronavirus pandemic, until the final stage to south coast city Nice set for Sunday was cancelled.
The competition, which was due to take place at Education City on March 13, has been postponed, due to worldwide coronavirus outbreak.
Over the previous 48 hours, several teams had withdrawn from the race, including Mitchelton, EF, Jumbo, Groupama-FDJ and Ineos.
The 12-member Groupama squad, which includes four riders, is also under quarantine.
Dolphin Energy staff took to training in Education City, ahead of the 2020 event, on March 13.