The Lions are on 32 points, but leaders Duhail can consolidate their position with a victory against Al Wakrah on Saturday.
Arabi stay fifth with 20 points, just one ahead of Al Wakrah.
Al Arabi play Al Shahania in Thursday's other match.
Former Eintracht Frankfurt player Fabian represented Mexico 43 times.
Yohan Boli scored the winner for Rayyan who are just two points behind leaders Duhail.
The win took Sadd's tally to 30 points, just three behind Duhail, who meet third-placed Rayyan in the second match of the day.
Mohamed Benyettou scored a double as Al Wakrah thrashed Al Shahania 4-1.
Al Sadd are third in the table, six points behind leaders Al Duhail
Lucca Borges scored a double including 95th-minute equaliser as Al Khor held Al Ahli to a 2-2 draw.
Al Sadd take on Al Sailiya in another big clash.
Boli is Al Rayyan's fifth foreign player along with Algerian Yacine Brahimi, Cameroonian Franck Kom, Argentine Gabriel Mercado, and Korean Lee Jae-Ik.
Al Duhail now are just two points ahead of second-placed Al Rayyan.
Pierre-Michelle Lassoga, Mohammed Salah El Neel and Morteza Pouraliganji scored for Al Arabi.
The Portuguese coach expects Mandzukic to solve his goal-scoring problems.
Mohamed Benyettou and Omar Ali scored Al Wakrah’s goals, while Hassan Al Haydous reduced the margin for Al Sadd late in the game.